The Holy Emperor Charles V and King Henry VIII of England became allies against France.
Source
The Treaty of Frankfurt was signed between Holy Roman Emperor Charles V and Protestants.
Henry VIII declared his marriage to Catherine of Aragon officially null and void, despite Pope Clement VII's refusal to allow it.
England and France declared war on Austria's Emperor, Charles V.
Pope Paul III excommunicated King Henry VIII of England.
Pope Clement V performed his first Coronation, making Charles V the Holy Roman Emperor.