Italian Artist Caravaggio signed his first commission contract to paint the Contarelli Chapel in the French church in Rome.
Source
The Fontana dei Quattro Fiumi, a fountain, was unveiled in Rome.
Galileo Galilei arrived in Rome for his trial before the Roman Inquisition.
The Great Fire of Rome started when the merchant shops around the Circus Maximus caught fire.
Michelangelo's Pietà in St. Peter's Basilica in Rome was vandalized.
The Sack of Rome occurred.