Italian Artist Caravaggio signed his first commission contract to paint the Contarelli Chapel in the French church in Rome.
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Michelangelo's Pietà in St. Peter's Basilica in Rome was vandalized.
Terrorists attacked Rome's Leonardo da Vinci–Fiumicino International Airport, leaving thirty dead.
The Sack of Rome occurred.
Pope Leo II became the bishop of Rome.
Romulus and Remus founded the city of Rome.